Multicenter Trial of Towne Strain Attenuated Virus Vaccine in Seronegative Renal Transplant Recipients

Transplantation. 1994 Dec 15;58(11):1176-8.


The Towne strain of attenuated CMV vaccine was compared with placebo in seronegative renal transplants who later received kidneys from seropositive donors. This was a double-blind, randomized, placebo-controlled trial conducted at 3 different institutions. The results were consistent with 2 prior studies, in that whereas mild CMV disease was only slightly and insignificantly reduced in vaccine recipients, severe disease was markedly reduced. In the current study, all 4 severe cases of CMV disease occurred in placebo recipients, for an incidence of 17%, versus 0% in vaccine recipients (P < 0.03). Thus, prior immunization rendered seronegative patients more resistant to the effects of CMV infection.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / blood*
  • Cytomegalovirus Infections / prevention & control*
  • Humans
  • Kidney Transplantation / immunology*
  • Vaccines, Attenuated / therapeutic use
  • Viral Vaccines / therapeutic use*


  • Vaccines, Attenuated
  • Viral Vaccines