A case of severe neonatal thrombocytopenia with schizencephaly associated with anti-HPA-1b and anti-HPA-2a

Br J Haematol. 1994 Jul;87(3):576-9. doi: 10.1111/j.1365-2141.1994.tb08315.x.


We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti-HPA-1b and anti-HPA-2a alloantibodies were detected. Third-generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Human Platelet / immunology*
  • Blood Platelets / immunology
  • Brain / abnormalities*
  • Cerebral Hemorrhage / congenital
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / immunology
  • Female
  • Fetal Diseases / etiology
  • Fetomaternal Transfusion / immunology*
  • Humans
  • Infant, Newborn
  • Isoantibodies / analysis*
  • Platelet Membrane Glycoproteins / immunology
  • Pregnancy
  • Receptors, Cell Surface / immunology
  • Thrombocytopenia / congenital*
  • Thrombocytopenia / immunology


  • Antigens, Human Platelet
  • Isoantibodies
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • von Willebrand factor receptor