Abstract
We report a family with a neonate who was severely damaged by intracranial haemorrhages. These probably occurred before the 20th week of gestation. The neonate had a moderate thrombocytopenia. In the maternal serum anti-HPA-1b and anti-HPA-2a alloantibodies were detected. Third-generation assays were applied to identify the alloantibodies. No other cause for the bleeding was found. Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy.
MeSH terms
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Antigens, Human Platelet / immunology*
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Blood Platelets / immunology
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Brain / abnormalities*
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Cerebral Hemorrhage / congenital
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Cerebral Hemorrhage / etiology*
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Cerebral Hemorrhage / immunology
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Female
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Fetal Diseases / etiology
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Fetomaternal Transfusion / immunology*
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Humans
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Infant, Newborn
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Isoantibodies / analysis*
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Platelet Membrane Glycoproteins / immunology
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Pregnancy
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Receptors, Cell Surface / immunology
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Thrombocytopenia / congenital*
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Thrombocytopenia / immunology
Substances
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Antigens, Human Platelet
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Isoantibodies
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Platelet Membrane Glycoproteins
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Receptors, Cell Surface
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von Willebrand factor receptor