Effect of timolol vs. acetazolamide on sodium hyaluronate-induced rise in intraocular pressure after cataract surgery

Can J Ophthalmol. 1994 Aug;29(4):182-6.


This prospective study was done to compare the efficacy of timolol and acetazolamide in lowering the intraocular pressure (IOP) secondary to the use of sodium hyaluronate (Healon) in cataract surgery. Fifty patients undergoing extracapsular cataract extraction and implantation of a posterior chamber lens were randomly assigned to one of four treatment groups: no viscoelastic (10 patients), Healon with 0.5% timolol drops postoperatively (12 patients), Healon with acetazolamide postoperatively (16 patients), or Healon only (12 patients). The IOP was measured during the first 24 hours after surgery. Sodium hyaluronate caused a marked increase in IOP in the early (6 to 12 hours) postoperative period. Timolol proved to be more effective than acetazolamide in controlling this pressure increase.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acetazolamide / administration & dosage
  • Acetazolamide / therapeutic use*
  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Cataract Extraction*
  • Female
  • Humans
  • Hyaluronic Acid / adverse effects*
  • Intraocular Pressure / drug effects*
  • Lenses, Intraocular
  • Male
  • Middle Aged
  • Ocular Hypertension / chemically induced
  • Ocular Hypertension / drug therapy*
  • Ophthalmic Solutions
  • Postoperative Complications
  • Prospective Studies
  • Timolol / administration & dosage
  • Timolol / therapeutic use*


  • Ophthalmic Solutions
  • Timolol
  • Hyaluronic Acid
  • Acetazolamide