Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 34 (8), 782-7

[Significance of Rimmed Vacuoles in Neuromuscular Disorders--A Comparative Immunohistochemical Study of Inclusion Body Myositis and Distal Myopathy With Rimmed Vacuole Formation]

[Article in Japanese]
Affiliations
  • PMID: 7994984
Comparative Study

[Significance of Rimmed Vacuoles in Neuromuscular Disorders--A Comparative Immunohistochemical Study of Inclusion Body Myositis and Distal Myopathy With Rimmed Vacuole Formation]

[Article in Japanese]
N Murakami et al. Rinsho Shinkeigaku.

Abstract

Of 3,403 muscle biopsies from patients with a variety of neuromuscular disorders, 87 (2.6%) had at least three muscle fibers with rimmed vacuoles in a single low power field (magnificantion x 20). The rimmed vacuole formation may be a crucial pathologic findings to understand the pathogenesis of inclusion body myositis (IBM), distal myopathy with rimmed vacuole formation (DMRV), Marinesco-Sjögren syndrome and oculopharyngodistal myopathy, because the muscle fibers in these biopsies showed no striking necrotic and denervating changes. Since Congo red positive material and ubiquitin- and beta-amyloid protein-positive deposits were found in muscle fibers with rimmed vacuoles in DMRV and various neuromuscular disorders besides IBM, these findings may have no disease-specific significance and may be not helpful in differentiating DMRV from IBM.

Similar articles

See all similar articles
Feedback