Amphetamine-like effect of l-deprenyl (selegiline) in drug discrimination studies

Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):768-73. doi: 10.1038/clpt.1994.207.


l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / pharmacology
  • Amphetamines / pharmacology*
  • Animals
  • Dextroamphetamine / pharmacology
  • Discrimination Learning / drug effects*
  • Dose-Response Relationship, Drug
  • Rats
  • Saimiri
  • Selegiline / pharmacology*


  • Amphetamines
  • Selegiline
  • Amphetamine
  • Dextroamphetamine