Clinical significance of plasma endothelin-1 in patients with chronic liver disease

Dig Dis Sci. 1994 Dec;39(12):2665-70. doi: 10.1007/BF02087707.

Abstract

To determine the clinical significance of plasma endothelin-1 in chronic liver disease, these levels were measured by radioimmunoassay. The plasma endothelin-1 levels in patients with cirrhosis (N = 16) (2.04 +/- 0.25 pg/ml) and patients with hepatocellular carcinoma (N = 22) (2.23 +/- 0.17 pg/ml) increased significantly compared with controls (N = 16) (1.17 +/- 0.17 pg/ml) and patients with chronic hepatitis (N = 11) (1.09 +/- 0.19 pg/ml) (P < 0.01). The presence of ascites rather than tumor volume was associated with a significant elevation of endothelin-1. Endothelin-1 showed significant negative correlations with parameters of hepatic function, including indocyanine green clearance, serum albumin, and prothrombin time. Although endothelin-1 was not correlated with plasma renin activity and plasma endotoxin, it demonstrated a significant positive correlation with the plasma level of atrial natriuretic peptide (r = 0.42, P < 0.01). These findings demonstrate that plasma endothelin-1 increased in proportion to the severity of liver damage and may be causally related with the derangement of systemic/renal hemodynamics and fluid and electrolyte homeostasis seen in advanced liver disease.

Publication types

  • Comparative Study

MeSH terms

  • Atrial Natriuretic Factor / blood
  • Carcinoma, Hepatocellular / blood*
  • Carcinoma, Hepatocellular / diagnosis
  • Endothelins / blood*
  • Female
  • Hepatitis, Chronic / blood*
  • Hepatitis, Chronic / diagnosis
  • Humans
  • Liver Cirrhosis / blood*
  • Liver Cirrhosis / diagnosis
  • Liver Function Tests
  • Liver Neoplasms / blood*
  • Liver Neoplasms / diagnosis
  • Male
  • Middle Aged
  • Radioimmunoassay
  • Renin / blood

Substances

  • Endothelins
  • Atrial Natriuretic Factor
  • Renin