Acquired von Willebrand disease in twins with autoimmune hypothyroidism: response to desmopressin and L-thyroxine therapy

J Pediatr. 1994 Dec;125(6 Pt 1):911-3. doi: 10.1016/s0022-3476(05)82007-4.


Because of menorrhagia, a 13-year-old girl was found to have type I von Willebrand disease and then chronic autoimmune thyroiditis with hypothyroidism. All clinical and laboratory evidence of von Willebrand disease resolved transiently after infusion of desmopressin, and permanently with L-thyroxine therapy. We recommend investigation for hypothyroidism in patients with newly diagnosed acquired von Willebrand disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Deamino Arginine Vasopressin / therapeutic use*
  • Diseases in Twins*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypothyroidism / etiology*
  • Infusions, Intravenous
  • Thyroiditis, Autoimmune / complications*
  • Thyroxine / therapeutic use*
  • von Willebrand Diseases / drug therapy*
  • von Willebrand Diseases / etiology*


  • Deamino Arginine Vasopressin
  • Thyroxine