Novel zinc chelators which inhibit the binding of HIV-EP1 (HIV enhancer binding protein) to NF-kappa B recognition sequence

J Med Chem. 1994 Dec 9;37(25):4267-9. doi: 10.1021/jm00051a002.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminopyridine / analogs & derivatives*
  • 4-Aminopyridine / chemistry
  • 4-Aminopyridine / pharmacology
  • Animals
  • Base Sequence
  • Binding Sites
  • Binding, Competitive
  • Chelating Agents / pharmacology*
  • DNA / chemistry
  • DNA / metabolism*
  • DNA-Binding Proteins / antagonists & inhibitors*
  • Edetic Acid / pharmacology
  • HIV Enhancer / drug effects*
  • Histidine / analogs & derivatives*
  • Histidine / chemistry
  • Histidine / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Sequence Data
  • NF-kappa B / metabolism*
  • Transcription Factors
  • Zinc / metabolism*

Substances

  • Chelating Agents
  • DNA-Binding Proteins
  • HIVEP1 protein, human
  • N,N'-(4-dimethylaminopyridine-2,6-diyl)-bis(histidine methyl ester)
  • NF-kappa B
  • Transcription Factors
  • Histidine
  • DNA
  • Edetic Acid
  • 4-Aminopyridine
  • Zinc