doi: 10.1038/372746a0.
Crystal structure of the tyrosine kinase domain of the human insulin receptor
Affiliations
- PMID: 7997262
- DOI: 10.1038/372746a0
Item in Clipboard
Crystal structure of the tyrosine kinase domain of the human insulin receptor
Nature.
1994 Dec.
Abstract
The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
Comment in
-
Signal transduction. Look at a tyrosine kinase.Nature. 1994 Dec 22-29;372(6508):726-7. doi: 10.1038/372726a0. Nature. 1994. PMID: 7997256 No abstract available.
Similar articles
-
Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact.Biochemistry. 1996 Aug 13;35(32):10377-82. doi: 10.1021/bi960350r. Biochemistry. 1996. PMID: 8756693
-
A basic residue, Lys 782, composes part of the ATP-binding site on the epidermal growth factor receptor tyrosine kinase.Arch Biochem Biophys. 1999 Mar 1;363(1):27-32. doi: 10.1006/abbi.1998.1052. Arch Biochem Biophys. 1999. PMID: 10049496
-
Modelling of insulin receptor tyrosine kinase in its active form: a case study for validation of theoretical methods.Acta Biochim Pol. 1999;46(3):601-7. Acta Biochim Pol. 1999. PMID: 10698268
-
Protein tyrosine kinase-substrate interactions.Curr Opin Struct Biol. 2006 Dec;16(6):668-75. doi: 10.1016/j.sbi.2006.10.012. Epub 2006 Nov 7. Curr Opin Struct Biol. 2006. PMID: 17085043 Review.
-
How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase.FASEB J. 1995 Oct;9(13):1255-66. doi: 10.1096/fasebj.9.13.7557015. FASEB J. 1995. PMID: 7557015 Review.
Cited by
-
Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.Iran J Basic Med Sci. 2021 Feb;24(2):232-239. doi: 10.22038/ijbms.2020.49770.11368. Iran J Basic Med Sci. 2021. PMID: 33953863 Free PMC article.
-
Identification and Optimization of Protein Tyrosine Phosphatase Inhibitors Via Fragment Ligation.Methods Mol Biol. 2024;2743:239-270. doi: 10.1007/978-1-0716-3569-8_16. Methods Mol Biol. 2024. PMID: 38147220
-
JAK/STAT in leukemia: a clinical update.Mol Cancer. 2024 Jan 26;23(1):25. doi: 10.1186/s12943-023-01929-1. Mol Cancer. 2024. PMID: 38273387 Free PMC article. Review.
-
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212909120. doi: 10.1073/pnas.2212909120. Epub 2023 Feb 6. Proc Natl Acad Sci U S A. 2023. PMID: 36745811 Free PMC article.
-
High predictive value of epidermal growth factor receptor phosphorylation but not of EGFRvIII mutation in resected stage I non-small cell lung cancer (NSCLC).J Clin Pathol. 2006 Mar;59(3):255-9. doi: 10.1136/jcp.2005.027615. J Clin Pathol. 2006. PMID: 16505275 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
