The SMS1 gene encoding a serine-rich transmembrane protein suppresses the temperature sensitivity of the htr1 disruptant in Saccharomyces cerevisiae

Biochim Biophys Acta. 1995 Jan 2;1260(1):94-6. doi: 10.1016/0167-4781(94)00188-9.


A new gene (SMS1; serine-rich multi-copy suppressor) of Saccharomyces cerevisiae was isolated by the ability to suppress the temperature sensitivity of the htr1 disruptant (Kikuchi et al. (1994) Mol. Gen. Genetics, in press) by increasing its gene dosage. The predicted gene product contains a serine-rich domain followed by a putative transmembrane region. The SMS1 gene was physically and genetically mapped in the region near cdc3 on chromosome XII R.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Fungal
  • DNA, Fungal
  • Fungal Proteins / genetics*
  • Gene Dosage
  • Membrane Transport Proteins*
  • Mitochondrial Membrane Transport Proteins
  • Molecular Sequence Data
  • Repressor Proteins / genetics*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Suppression, Genetic*
  • Temperature


  • DNA, Fungal
  • Fungal Proteins
  • Membrane Transport Proteins
  • Mitochondrial Membrane Transport Proteins
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • TIM17 protein, S cerevisiae

Associated data

  • GENBANK/D29964