Pulmonary infiltration with eosinophilia and increased serum levels of squamous cell carcinoma-related antigen and neuron specific enolase

Intern Med. 1994 Sep;33(9):550-3. doi: 10.2169/internalmedicine.33.550.

Abstract

We report a case of pulmonary infiltration with eosinophilia (PIE), associated with increased serum levels of squamous cell carcinoma-related antigen (SCC) and neuron specific enolase (NSE). The diagnosis of PIE was confirmed by examination of bronchoalveolar lavage fluid and specimens of transbronchial lung biopsy. It was suggested that PIE was probably induced by a course of amoxicillin for a sore throat. Corticosteroid therapy resulted in clinical improvement of symptoms, resolution of pulmonary infiltrates on chest roentgenogram and reduction in serum levels of SCC and NSE.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Aged
  • Amoxicillin / adverse effects*
  • Antigens, Neoplasm / blood*
  • Biomarkers, Tumor / blood*
  • Carcinoma, Squamous Cell / diagnosis
  • Diagnosis, Differential
  • False Positive Reactions
  • Humans
  • Male
  • Phosphopyruvate Hydratase / blood*
  • Pulmonary Eosinophilia / blood
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / diagnosis
  • Pulmonary Eosinophilia / drug therapy
  • Serpins*

Substances

  • Adrenal Cortex Hormones
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Serpins
  • squamous cell carcinoma-related antigen
  • Amoxicillin
  • Phosphopyruvate Hydratase