[Clinical study on prevention and treatment to chemotherapy caused nephrotoxicity with jian-pi yi-qi li-shui Decoction]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Jun;14(6):331-3, 323.
[Article in Chinese]

Abstract

95 cases of cancer patients were treated with large dose of Cisplatinum. They were randomly divided into treated group with Chinese medicinal herbs (49 cases) and control group with hydration treatment (46 cases). Multiple indexes were selected to observe effect on renal function. The result showed that the level of blood urea nitrogen (BUN), creatnine (Cr), beta 2 microglobulin (beta 2-MG), urea N-acetyl-beta-glucosaminidase (NAG) of treated group lowered. After treatment the difference of BUN, Cr between the two groups was significant (P < 0.05). It suggested that Jian-Pi Yi-Qi Li-Shui Decoction (JPYQLSD) was superior to hydration group in preventing the large dose of Cisplatinum induced nephrotoxicity. It was also used to treat 44 cases-times of chemotherapy caused renal failure. The total effect rate is 93.18%. The difference of the level of BUN, Cr between before and after treatment was very significant (P < 0.01). It is proved that JPYQLSD has good effect in treating chemotherapy caused renal failure.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acetylglucosaminidase / metabolism
  • Adolescent
  • Adult
  • Aged
  • Blood Urea Nitrogen
  • Cisplatin / adverse effects*
  • Creatinine / blood
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Lung Neoplasms / drug therapy
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / drug therapy
  • Renal Insufficiency / chemically induced
  • Renal Insufficiency / drug therapy*
  • Renal Insufficiency / metabolism
  • beta 2-Microglobulin / metabolism

Substances

  • Drugs, Chinese Herbal
  • beta 2-Microglobulin
  • Creatinine
  • Acetylglucosaminidase
  • Cisplatin