Abstract
A practical integrated process, combining an enzymatic resolution step with a few chemical transformations, is described for the synthesis of (1R, 4R)- and (2S, 4S)-bicyclo[2.2.1]heptan-2,5-diones 1 of high enantiomeric purity, starting from a standard mixture of (+/-)-endo- and exo-2-acetoxy-5-norbornene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Candida / enzymology
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Carbohydrate Conformation
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Chromatography, Gas
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Crystallization
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Indicators and Reagents
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Lipase*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Norbornanes / chemical synthesis*
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Norbornanes / chemistry*
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Norbornanes / isolation & purification
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Optical Rotation
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Stereoisomerism
Substances
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Indicators and Reagents
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Norbornanes
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2-acetoxy-5-norbornene
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Lipase