The MO15 Cell Cycle Kinase Is Associated With the TFIIH transcription-DNA Repair Factor

Cell. 1994 Dec 16;79(6):1093-101. doi: 10.1016/0092-8674(94)90039-6.

Abstract

A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cell Cycle / physiology*
  • Cell Nucleus / metabolism
  • Cyclin-Dependent Kinases*
  • DNA Repair*
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments / metabolism
  • Phosphorylation
  • Protein Binding
  • Protein-Serine-Threonine Kinases / immunology
  • Protein-Serine-Threonine Kinases / isolation & purification
  • Protein-Serine-Threonine Kinases / metabolism*
  • RNA Polymerase II / metabolism
  • Transcription Factor TFIIH
  • Transcription Factors / immunology
  • Transcription Factors / isolation & purification
  • Transcription Factors / metabolism*
  • Transcription Factors, TFII*
  • Transcription, Genetic*

Substances

  • Peptide Fragments
  • Transcription Factors
  • Transcription Factors, TFII
  • Transcription Factor TFIIH
  • Protein-Serine-Threonine Kinases
  • Cyclin-Dependent Kinases
  • cyclin-dependent kinase-activating kinase
  • RNA Polymerase II