Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 79 (7), 1165-73

Ectopic Expression of Sonic Hedgehog Alters Dorsal-Ventral Patterning of Somites

Affiliations

Ectopic Expression of Sonic Hedgehog Alters Dorsal-Ventral Patterning of Somites

R L Johnson et al. Cell.

Abstract

Differentiation of somites into sclerotome, dermatome, and myotome is controlled by a complex set of inductive interactions. The ability of axial midline tissues, the notochord and floor plate, to induce sclerotome has been well documented and has led to models in which ventral somite identity is specified by signals derived from the notochord and floor plate. Herein, we provide evidence that Sonic hedgehog, a vertebrate homolog of the Drosophila segment polarity gene hedgehog, is a signal produced by the notochord and floor plate that directs ventral somite differentiation. Sonic hedgehog is expressed in ventral midline tissues at critical times during somite specification and has the ability, when ectopically expressed, to enhance the formation of sclerotome and antagonize the development of dermatome.

Similar articles

See all similar articles

Cited by 55 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback