Characterization of the aac(6')-Ik gene of Acinetobacter sp. 6

FEMS Microbiol Lett. 1994 Nov 15;124(1):49-54. doi: 10.1016/0378-1097(94)90331-x.


The aac(6')-Ik gene which confers resistance to aminoglycosides in Acinetobacter sp. 6 CIP A165 was characterized. The resistance gene was identified as a coding sequence of 438 bases pairs corresponding to a protein with a calculated mass of 16627 Da. Alignment of aac(6')-Ik with aac(6')-Ig from Acinetobacter haemolyticus indicated 83% identity. Like aac(6')-Ig of A. haemolyticus and aac(6')-Ij of Acinetobacter sp. 13, the aac(6')-Ik gene was apparently located in the chromosome and was species specific. The high degree of identity between aac(6')-Ig and -Ik, compared with genomic DNA relationships between the host species, indicated that these genes have diverged from a common ancestor in a parental Acinetobacter species.

MeSH terms

  • Acetyltransferases / genetics*
  • Acetyltransferases / metabolism
  • Acinetobacter / drug effects
  • Acinetobacter / genetics*
  • Amino Acid Sequence
  • Aminoglycosides / pharmacology*
  • Base Sequence
  • Cloning, Molecular
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial / genetics*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Species Specificity


  • Aminoglycosides
  • Acetyltransferases
  • aminoglycoside N(6')-acetyltransferase

Associated data

  • GENBANK/L29510