Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein

Genomics. 1994 Aug;22(3):610-6. doi: 10.1006/geno.1994.1434.


Since the realization that the vesicular transport machinery is conserved from yeast to vertebrate neurons, much interest in the proteins involved has been generated. Here we describe a new type of mammalian YPT/Rab protein, named Rab11b, that is most abundantly expressed in brain, heart, and testis. It has all the hallmarks of a YPT3/Rab11 protein, but is more closely related to a ypt3-related gene isolated from fish (97% homology) than to the previously described four mammalian Rab11 genes (89% homology). The mammalian Rab11 genes discovered previously are, by contrast, 100% identical to each other. The genomic structure of a mammalian Rab11 protein is described for the first time. It is surprisingly asymmetrical, with 96% of the coding sequence contained in one-third of the transcription unit. Two copies of this gene are mapped to mouse chromosomes 1 and 17. The fine structural analysis of Rab11b and the protein sequence comparison provides a close look at all YPT3/Rab11-related genes cloned so far and clues to their possible relationship.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Conserved Sequence
  • DNA / genetics
  • Fungal Proteins / genetics
  • GTP-Binding Proteins / genetics*
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Multigene Family
  • Schizosaccharomyces pombe Proteins*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • rab GTP-Binding Proteins*


  • Fungal Proteins
  • Schizosaccharomyces pombe Proteins
  • ypt3 protein, S pombe
  • DNA
  • GTP-Binding Proteins
  • rab11 protein
  • rab GTP-Binding Proteins

Associated data

  • GENBANK/L26528