Combination effect of meropenem with aminoglycosides and teicoplanin on Pseudomonas and enterococci

Infection. Jul-Aug 1994;22(4):306-8. doi: 10.1007/BF01739926.

Abstract

The in vitro activity of meropenem, a new carbapenem, and the combination effect with netilmicin, tobramycin, gentamicin, and teicoplanin against Pseudomonas spp. and enterococci was studied. Meropenem showed very good in vitro activity against Pseudomonas aeruginosa (MIC90 2 mg/l) and good to moderate activity against Pseudomonas putida (MIC90 4 mg/l) and Enterococcus faecalis (MIC90 8 mg/l). Aminoglycosides were highly active against P. putida (MIC90 0.5 mg/l), but showed only moderate activity against P. aeruginosa. The synergistic effect of meropenem was shown in combination with teicoplanin against E. faecalis (40%). No Pseudomonas strains were inhibited by the synergistic effect of meropenem with aminoglycosides. No antagonism occurred with any of the combinations.

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / therapeutic use
  • Cross Infection / drug therapy*
  • Cross Infection / microbiology
  • Drug Evaluation, Preclinical
  • Drug Synergism
  • Drug Therapy, Combination / therapeutic use*
  • Enterococcus faecalis*
  • Gram-Positive Bacterial Infections / drug therapy*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Meropenem
  • Microbial Sensitivity Tests
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / microbiology
  • Teicoplanin / therapeutic use
  • Thienamycins / therapeutic use

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Thienamycins
  • Teicoplanin
  • Meropenem