Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

R Sawa; Y Takahashi; S Itoh; K Shimanaka; N Kinoshita; Y Homma; M Hamada; T Sawa; H Naganawa; T Takeuchi

doi:10.7164/antibiotics.47.1266

Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

J Antibiot (Tokyo). 1994 Nov;47(11):1266-72. doi: 10.7164/antibiotics.47.1266.

Authors

R Sawa¹, Y Takahashi, S Itoh, K Shimanaka, N Kinoshita, Y Homma, M Hamada, T Sawa, H Naganawa, T Takeuchi

Affiliation

¹ Institute of Microbial Chemistry, Tokyo, Japan.

PMID: 8002389
DOI: 10.7164/antibiotics.47.1266

Abstract

A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The 1H and 13C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).

MeSH terms

Anti-Bacterial Agents / isolation & purification*
Fermentation
Pyrans / chemistry
Pyrans / isolation & purification
Pyrans / pharmacology
Streptomyces / classification
Streptomyces / metabolism*

Substances

Anti-Bacterial Agents
Pyrans
aldecalmycin