The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761

Biochem Biophys Res Commun. 1994 Jun 15;201(2):748-55. doi: 10.1006/bbrc.1994.1764.

Abstract

Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.

MeSH terms

  • Animals
  • Catalase / metabolism*
  • Cattle
  • Free Radical Scavengers*
  • Ginkgo biloba
  • Glucose Oxidase / metabolism*
  • Kinetics
  • Nitric Oxide* / chemistry
  • Nitrites / analysis
  • Nitroprusside / chemistry*
  • Oxyhemoglobins / chemistry
  • Oxyhemoglobins / metabolism
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*

Substances

  • Free Radical Scavengers
  • Nitrites
  • Oxyhemoglobins
  • Plant Extracts
  • Nitroprusside
  • Ginkgo biloba extract
  • Nitric Oxide
  • Glucose Oxidase
  • Catalase