Long-term Effect of omega-3 Fatty Acid Supplementation in Active Rheumatoid Arthritis. A 12-month, Double-Blind, Controlled Study

Arthritis Rheum. 1994 Jun;37(6):824-9. doi: 10.1002/art.1780370608.

Abstract

Objective: To study the long-term effects of supplementation with omega-3 fatty acids (omega 3) in patients with active rheumatoid arthritis.

Methods: Ninety patients were enrolled in a 12-month, double-blind, randomized study comparing daily supplementations with either 2.6 gm of omega 3, or 1.3 gm of omega 3 + 3 gm of olive oil, or 6 gm of olive oil.

Results: Significant improvement in the patient's global evaluation and in the physician's assessment of pain was observed only in those taking 2.6 gm/day of omega 3. The proportions of patients who improved and of those who were able to reduce their concomitant antirheumatic medications were significantly greater with 2.6 gm/day of omega 3.

Conclusion: Daily supplementation with 2.6 gm of omega 3 results in significant clinical benefit and may reduce the need for concomitant antirheumatic medication.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / diet therapy*
  • Arthritis, Rheumatoid / drug therapy
  • Double-Blind Method
  • Fatty Acids, Omega-3 / administration & dosage*
  • Female
  • Fish Oils / administration & dosage
  • Food, Fortified
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Severity of Illness Index*
  • Time Factors
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Fatty Acids, Omega-3
  • Fish Oils