Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies

Arthritis Rheum. 1994 Jun;37(6):902-6. doi: 10.1002/art.1780370619.


Objective: To determine racial differences in the frequencies of systemic sclerosis (SSc)-related serum antinuclear antibodies (ANA).

Methods: We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc-related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays.

Results: In comparing the 3 racial groups, we found that anti-U1 RNP, anti-RNA polymerase I, II, and III, and anti-U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti-PM-Scl antibody was found exclusively in Caucasians.

Conclusion: The production of SSc-related serum ANA is related to immunogenetic background.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group*
  • Antibodies, Antinuclear / blood*
  • Asian Continental Ancestry Group*
  • Autoimmune Diseases / blood
  • Autoimmune Diseases / ethnology*
  • Autoimmune Diseases / immunology
  • European Continental Ancestry Group*
  • Humans
  • Japan
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / ethnology*
  • Scleroderma, Systemic / immunology
  • United States


  • Antibodies, Antinuclear