Treatment of stiff-man syndrome with intravenous immune globulin

Arthritis Rheum. 1994 Jun;37(6):915-8. doi: 10.1002/art.1780370621.


Objective: To evaluate the efficacy of intravenous immune globulin (IVIG) in the treatment of stiff-man syndrome (SMS).

Methods: An open, unblinded study of 3 patients with active disease and/or disease refractory to treatment with diazepam and/or corticosteroids.

Results: All 3 bedridden patients improved substantially shortly after infusion with IVIG and regained function.

Conclusion: IVIG may be useful for the treatment of SMS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Middle Aged
  • Stiff-Person Syndrome / complications
  • Stiff-Person Syndrome / therapy*


  • Immunoglobulins, Intravenous