Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial

J Pediatr Orthop. May-Jun 1994;14(3):299-303. doi: 10.1097/01241398-199405000-00005.


In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Botulinum Toxins / administration & dosage
  • Botulinum Toxins / therapeutic use*
  • Cerebral Palsy / complications
  • Cerebral Palsy / drug therapy*
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Foot Deformities, Acquired / drug therapy*
  • Foot Deformities, Acquired / etiology
  • Gait
  • Humans
  • Injections, Intramuscular
  • Muscle Spasticity / drug therapy
  • Range of Motion, Articular


  • Botulinum Toxins