Antibiotic induced meningitis

J Neurol Neurosurg Psychiatry. 1994 Jun;57(6):705-8. doi: 10.1136/jnnp.57.6.705.


Three patients with antibiotic induced meningitis, one following penicillin with seven episodes, are reported on--the first well documented description of penicillin induced meningitis. In this patient episodes of headache and nuchal rigidity appeared with and without CSF pleocytosis. Two patients had a total of five episodes of antibiotic induced meningitis after trimethoprim-sulphamethoxazole (co-trimoxazole) administration. The features common to all three patients were myalgia, confusion and low CSF glucose. CSF analysis was not a reliable method to differentiate antibiotic induced meningitis from partially treated bacterial meningitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Aged
  • Aged, 80 and over
  • Cerebrospinal Fluid / chemistry
  • Cerebrospinal Fluid / cytology
  • Confusion / etiology
  • Diagnosis, Differential
  • Female
  • Glucose / analysis
  • Headache / etiology
  • Humans
  • Male
  • Meningitis / cerebrospinal fluid
  • Meningitis / chemically induced*
  • Meningitis / complications
  • Meningitis / epidemiology
  • Muscle Rigidity
  • Neck Muscles
  • Penicillins / adverse effects*
  • Recurrence
  • Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects*


  • Penicillins
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Glucose