Depression in Parkinson's disease

Am J Psychiatry. 1994 Jul;151(7):1010-4. doi: 10.1176/ajp.151.7.1010.


Objective: The authors assessed the prevalence of major depression (DSM-III-R) among Parkinson's disease patients and compared this rate with that of matched physically disabled subjects.

Method: The 30-item General Health Questionnaire and measures of physical disability were completed by all patients in Dunedin, New Zealand, identified as having Parkinson's disease. Patients scoring over 5 on the General Health Questionnaire were interviewed with the Structured Clinical Interview for DSM-III-R--Non-Patient Version. Each patient living in the community was matched for age, sex, and level of physical disability with a comparison subject who did not have a neurological condition.

Results: Of the 73 subjects with Parkinson's disease who agreed to participate and were judged not to be demented, 34.2% scored higher than 5 on the 30-item General Health Questionnaire, but only 2.7% met the criteria for major depression. No difference from the comparison group was found.

Conclusions: The prevalence of major depression in patients with Parkinson's disease may be no greater than in age- and sex-matched physically disabled persons.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Comorbidity
  • Depressive Disorder / diagnosis
  • Depressive Disorder / epidemiology*
  • Depressive Disorder / etiology
  • Disabled Persons / statistics & numerical data
  • Female
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • New Zealand / epidemiology
  • Parkinson Disease / complications
  • Parkinson Disease / diagnosis
  • Parkinson Disease / epidemiology*
  • Prevalence
  • Psychiatric Status Rating Scales