Regulation of gene expression at early stages of B-cell differentiation

Curr Opin Immunol. 1994 Apr;6(2):222-30. doi: 10.1016/0952-7915(94)90095-7.


The phenotype of B lymphocytes at various stages of differentiation is, in part, controlled at the transcriptional level. Recently, a number of B-cell lineage and stage-specific transcription factors have been identified as candidate determinants for the developmental regulation of gene expression in B lymphocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology*
  • Base Sequence
  • Cell Differentiation / physiology*
  • Enhancer Elements, Genetic
  • Gene Expression Regulation / physiology*
  • Helix-Loop-Helix Motifs / physiology
  • Immune System / growth & development
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Transcription Factors / physiology


  • Transcription Factors