Natriuretic action of angiotensin(1-7)

Br J Pharmacol. 1994 Jan;111(1):1-3. doi: 10.1111/j.1476-5381.1994.tb14014.x.

Abstract

Evidence that angiotensin(1-7) (Ang(1-7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1-7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1-7) may participate in the renal effects of the renin-angiotensin system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiotensin I
  • Angiotensin II / pharmacology*
  • Animals
  • Diuresis / drug effects
  • Glomerular Filtration Rate / drug effects*
  • Kidney / blood supply
  • Kidney / drug effects
  • Kidney Tubules / drug effects
  • Male
  • Natriuresis / drug effects*
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Vascular Resistance / drug effects

Substances

  • Peptide Fragments
  • Angiotensin II
  • Angiotensin I
  • angiotensin I (1-7)