Superinfection exclusion by T-even-type coliphages

Trends Microbiol. 1994 Apr;2(4):137-9. doi: 10.1016/0966-842x(94)90601-7.


When a bacterial cell is infected with a T-even coliphage, immunity to a superinfecting phage is rapidly established (superinfection exclusion). Two phage-encoded proteins, Imm and Sp, are responsible for this exclusion: Imm blocks DNA transfer across the plasma membrane and partially inhibits release of DNA from the superinfecting virion, and Sp inhibits local degradation of bacterial murein by a phage-associated lysozyme.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Molecular Sequence Data
  • T-Phages / genetics
  • T-Phages / physiology*
  • Virus Replication