Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study

Genet Epidemiol. 1994;11(1):51-67. doi: 10.1002/gepi.1370110106.


Sibling correlations were evaluated and segregation analysis was performed on age-dependent maculopathy scores of the right and left eyes of individuals from 564 families in the Beaver Dam Eye study. There is evidence of significant sibling correlations. The data fit a mixture of two normal distributions, especially after undergoing the Box and Cox power transformation. In each eye, the hypothesis of mendelian transmission of a major effect cannot be rejected under the tau AB free model, but is rejected under the tau's free model. The hypothesis of a random environmental major effect is rejected. Similar major gene parameter estimates are found for both eyes. The results are consistent with a major effect accounting for 62% and 59%, in the right and left eyes, respectively, of the determination of age-related maculopathy scores. A single major gene can account for about 89% and 97% of this variability due to a major effect, or for about 55% and 57% of the total variability, in the right and left eyes, respectively.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Bias
  • Chromosome Mapping*
  • Environment
  • Female
  • Genes, Dominant
  • Genetic Variation*
  • Humans
  • Likelihood Functions
  • Macular Degeneration / classification
  • Macular Degeneration / diagnosis
  • Macular Degeneration / epidemiology*
  • Macular Degeneration / genetics*
  • Male
  • Middle Aged
  • Models, Genetic*
  • Normal Distribution
  • Pedigree*
  • Regression Analysis
  • Severity of Illness Index
  • Wisconsin / epidemiology