Resting energy expenditure in infants with cystic fibrosis

J Pediatr Gastroenterol Nutr. 1994 Feb;18(2):214-9. doi: 10.1097/00005176-199402000-00015.


To evaluate the contribution of energy expenditure to the energy imbalance seen in cystic fibrosis patients, resting energy expenditure was measured using open-circuit indirect calorimetry in eight infants with cystic fibrosis, aged 2-7 months (mean, 4), without overt lung disease and in 10 healthy age-matched controls. In both groups, we found close, significant, linear correlations between resting energy expenditure and body weight and between resting energy expenditure and fat-free mass as measured by anthropometry. Cystic fibrosis patients had a 26% increase in resting energy expenditure per kilogram of fat-free mass as compared with controls and a 32% increase in resting energy expenditure as compared with predicted values for fat-free mass. These data from young infants free of clinical symptoms suggest a constitutional metabolic disorder in cystic fibrosis and support the need for early nutritional therapy in cystic fibrosis patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Basal Metabolism
  • Cystic Fibrosis / metabolism*
  • Eating
  • Energy Metabolism / physiology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Rest