A novel tRNA species as an origin of short interspersed repetitive elements (SINEs). Equine SINEs may have originated from tRNA(Ser)

J Mol Biol. 1994 Jun 24;239(5):731-5. doi: 10.1006/jmbi.1994.1410.


Short interspersed repetitive elements (SINEs) were isolated from the equine genome and characterized. The equine SINE (ERE-1) family has several features characteristic of tRNA-derived retroposons. The five members of the equine family of SINEs are approximately 230 nucleotides in length and terminate with a sequence rich in oligo(A). They are all flanked by direct repeats at the 5' and 3' ends, and such repeats are the hallmarks of retroposons. In addition, the ERE-1 family has a tRNA-related region, which is similar to tRNA(Ser) of Drosophila (65% identity). tRNA(Ser) is a novel tRNA with respect to the origin of SINEs and has not previously been recognized among the twenty tRNA-derived SINEs characterized to date. The members of the ERE-1 family were found to be distributed among five species in the genus Equus, and their amplification may have contributed to the genetic variability of their hosts during evolution.

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • Drosophila / genetics
  • Horses / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Transfer*
  • RNA, Transfer, Ser
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment


  • RNA, Transfer, Ser
  • RNA, Transfer

Associated data

  • GENBANK/D26565
  • GENBANK/D26566
  • GENBANK/D26567
  • GENBANK/D26568
  • GENBANK/D26569