Leukotrien B4-induced interleukin-1 beta in synovial cells from patients with rheumatoid arthritis

Scand J Rheumatol. 1994;23(3):148-50. doi: 10.3109/03009749409103049.


We examined the role of Leukotrien B4 (LTB4) in the production of Interleukin-1 beta (IL-1 beta) by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis. The production of IL-1 beta was augmented by LTB4 at concentrations of 10(-9) to 10(-8) M. Furthermore, LTB4 showed the additive effect on the IL-1 beta production with interferon-gamma but not with lipopolysaccharide. These results suggest that LTB4 in cooperation with certain cytokines might play a pivotal role in the IL-1 beta production by rheumatoid synovial cells in vivo.

MeSH terms

  • Arthritis, Rheumatoid / metabolism*
  • Arthritis, Rheumatoid / pathology
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Humans
  • Interleukin-1 / metabolism*
  • Leukotriene B4 / pharmacology*
  • Lipopolysaccharides / pharmacology
  • Osmolar Concentration
  • Synovial Membrane / metabolism*
  • Synovial Membrane / pathology


  • Interleukin-1
  • Lipopolysaccharides
  • Leukotriene B4