Multicentric giant cell tumor: report of five new cases

Skeletal Radiol. 1994 Apr;23(3):187-90. doi: 10.1007/BF00197457.

Abstract

The typical giant cell tumor (GCT) is a solitary neoplams that occurs in the epiphysis or epimetaphysis of long bones. GCT is seen with a slightly increased frequency in females, and 70% of patients are between 20 and 40 years of age at the time of presentation. Multicentric giant cell tumor (MGCT; two or more centers) is an unusual variant of GCT. Patients with MGCT are likely to be younger than those with a solitary lesion. The multicentric variety is often of a higher stage at diagnosis and is more often associated with a pathological fracture than the unifocal tumor. We are reporting five new cases of MGCT, with a total of 21 tumors seen over a period of 25 years from 1967 to 1992.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Bone Neoplasms / pathology*
  • Calcaneus / pathology
  • Child
  • Female
  • Femoral Neoplasms / pathology
  • Fibula / pathology
  • Fingers / pathology
  • Giant Cell Tumor of Bone / pathology*
  • Humans
  • Humerus / pathology
  • Male
  • Neoplasm Recurrence, Local / pathology
  • Pelvic Bones / pathology
  • Radius / pathology
  • Tibia / pathology