Poly(ADP-ribose) polymerase: a molecular nick-sensor

Trends Biochem Sci. 1994 Apr;19(4):172-6. doi: 10.1016/0968-0004(94)90280-1.


Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Poly Adenosine Diphosphate Ribose / biosynthesis
  • Poly(ADP-ribose) Polymerases* / chemistry
  • Poly(ADP-ribose) Polymerases* / genetics
  • Poly(ADP-ribose) Polymerases* / metabolism
  • Repetitive Sequences, Nucleic Acid


  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases