Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes

Biochim Biophys Acta. 1994 Jun 21;1218(2):221-4. doi: 10.1016/0167-4781(94)90017-5.


Screening of a mouse spleen genomic DNA library with mouse BMP-4 and BMP-2 cDNA probes led to the isolation of mouse BMP-2 gene. This gene contains approximately 11 kb transcription unit and 3 exons. The deduced protein has 394 amino acids. The C-terminal amino acid mature coding region is identical to that of the human BMP-2. Comparison of mouse BMP-2 and BMP-4 gene shows little similarity in exon/intron structure, although the mature coding peptide regions of both genes share over 90% identity at the amino acid level.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bone Morphogenetic Proteins
  • Growth Substances / genetics*
  • Mice
  • Molecular Sequence Data
  • Proteins / genetics*
  • Restriction Mapping


  • Bone Morphogenetic Proteins
  • Growth Substances
  • Proteins

Associated data

  • GENBANK/L25602