The origin of isochromosomes and their significance in tumorigenesis of human lung cancer

S B Fu; P Li; X L Feng; C X Liu; Q Z Liu

doi:10.1016/0165-4608(94)90009-4

The origin of isochromosomes and their significance in tumorigenesis of human lung cancer

Cancer Genet Cytogenet. 1994 Jun;74(2):120-2. doi: 10.1016/0165-4608(94)90009-4.

Authors

S B Fu¹, P Li, X L Feng, C X Liu, Q Z Liu

Affiliation

¹ Department of Biology, Harbin Medical College, China.

PMID: 8019955
DOI: 10.1016/0165-4608(94)90009-4

Abstract

Isochromosomes related to chromosomes 1, 5, 6, 8, and 9 were frequently observed in 23 cases of lung cancer. Their existence in tumor cells might be nonrandom. Premature centromere separation (PCS) was found in the PGT-131 cell line of a lung cancer. It is suggested that PCS may play a role in the formation of isochromosomes in lung cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / genetics*
Carcinoma, Squamous Cell / genetics*
Cell Line
Chromosome Aberrations*
Humans
Lung Neoplasms / genetics*
Lymphatic Metastasis