The complete sequence of a human astrovirus

J Gen Virol. 1994 Jul;75 ( Pt 7):1785-8. doi: 10.1099/0022-1317-75-7-1785.


We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3' ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • Genes, Viral / genetics*
  • Genome, Viral*
  • Humans
  • Mamastrovirus / classification
  • Mamastrovirus / genetics*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Open Reading Frames / genetics
  • RNA Replicase / genetics
  • Sequence Analysis, DNA
  • Serine Endopeptidases / genetics
  • United Kingdom


  • RNA Replicase
  • Serine Endopeptidases

Associated data

  • GENBANK/Z25771