Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport

Mol Microbiol. 1994 Mar;11(5):841-7. doi: 10.1111/j.1365-2958.1994.tb00362.x.

Abstract

Homology has been established for members of two families of functionally related bacterial membrane proteins. The first family (the resistance/nodulation/cell division (RND) family) includes (i) two metal-resistance efflux pumps in Alcaligenes eutrophus (CzcA and CnrA), (ii) three proteins which function together in nodulation of alfalfa roots by Rhizobium meliloti (NoIGHI), and (iii) a cell division protein in Escherichia coli (EnvD). The second family (the putative membrane fusion protein (MFP) family) includes a nodulation protein (NoIF), a cell division protein (EnvC), and a multidrug resistance transport protein (EmrA). We propose that an MFP functions co-operatively with an RND protein to transport large or hydrophobic molecules across the two membranes of the Gram-negative bacterial cell envelope.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcaligenes / chemistry
  • Alcaligenes / genetics
  • Alcaligenes / physiology*
  • Amino Acid Sequence
  • Bacterial Outer Membrane Proteins / classification
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism
  • Bacterial Proteins / classification*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Biological Transport / genetics
  • Carrier Proteins / classification*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cell Division / genetics
  • Consensus Sequence
  • Drug Resistance, Microbial / genetics
  • Escherichia coli / chemistry
  • Escherichia coli / genetics
  • Escherichia coli / physiology*
  • Escherichia coli Proteins*
  • Genes, Bacterial
  • Medicago sativa / microbiology
  • Membrane Proteins / classification*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Metals / pharmacology
  • Molecular Sequence Data
  • Multidrug Resistance-Associated Proteins
  • Multigene Family
  • Operon
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sinorhizobium meliloti / chemistry
  • Sinorhizobium meliloti / genetics
  • Sinorhizobium meliloti / physiology*

Substances

  • AcrB protein, E coli
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Carrier Proteins
  • EmrA protein, E coli
  • Escherichia coli Proteins
  • Membrane Proteins
  • Metals
  • Multidrug Resistance-Associated Proteins
  • acrF protein, E coli
  • emrA protein, Bacteria