[Trichomonacidal activity of newly synthesized derivatives of benzoizothiazolinon (BIT) in vitro]

Wiad Parazytol. 1994;40(1):59-64.
[Article in Polish]


Trichomonacidal activity in vitro of 2 newly synthesized derivatives of benzoizothiazolinon (BIT) in comparison with metronidazole was determined by calculating lethal concentration for 50% trichomonal population (C50). Experiments were carried out on 2 strains of T. vaginalis and 2 strains of T. anseris. Both preparations showed considerably higher trichomonacidal activity than metronidazole. Mean values of trichomonacidal activity of N-morpholinomethyl-1,2-benzoizothiazolinon-3 for T. vaginalis and T. anseris amounted to 885 and 1997 respectively, and were 6 and 8 times higher than those of hydrochloride of N-piperydynomethyloamide of (5-chloro-1,2-benzoizothiazolinon-3ylo-2)-acetic acid. The lowest trichomonacidal activity of hydrochloride of N-piperydynomethylamide of (5-chloro-1,2-benzoizotiazolinon-3ylo-2)-acetic acid was 10-fold higher than that of N-morpholinomethyl-1,2-benzoizothiazolinon-3 and several hundred times lower than metronidazole concentration.

Publication types

  • English Abstract

MeSH terms

  • Acetamides / pharmacology*
  • Animals
  • Antitrichomonal Agents / chemistry
  • Antitrichomonal Agents / pharmacology*
  • In Vitro Techniques
  • Metronidazole / pharmacology
  • Piperidines / pharmacology*
  • Species Specificity
  • Thiazoles / pharmacology*
  • Trichomonas / drug effects*
  • Trichomonas vaginalis / drug effects*


  • Acetamides
  • Antitrichomonal Agents
  • N-morpholinomethyl-1,2-benzoisothiazolin-3-one
  • N-piperidinylmethyl-5-chloro-1,2-benzisothiazolin-3-one-2-acetamide
  • Piperidines
  • Thiazoles
  • Metronidazole