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Comparative Study
, 12 (5), 439-44

A Conventionally Attenuated Glycoprotein E-negative Strain of Bovine Herpesvirus Type 1 Is an Efficacious and Safe Vaccine

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Comparative Study

A Conventionally Attenuated Glycoprotein E-negative Strain of Bovine Herpesvirus Type 1 Is an Efficacious and Safe Vaccine

M J Kaashoek et al. Vaccine.

Abstract

We examined the vaccine properties of a conventionally attenuated bovine herpesvirus type 1 (BHV-1) mutant strain A. This strain has a deletion that encompasses the glycoprotein E gene and may therefore be used as a marker vaccine. We compared strain A with a commercial live BHV-1 vaccine B. Calves were intranasally vaccinated with strain A or with vaccine B. Strain A was virtually avirulent for young calves. After challenge, vaccinated calves were protected against disease and virus shedding was considerably reduced. After dexamethasone treatment, strain A was not recovered, whereas vaccine B and challenge virus were. We conclude that strain A is suitable for inclusion in a vaccine and has the potential advantage of being used as a marker vaccine.

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