Induction of experimental allergic arthritis with outer surface proteins of Borrelia burgdorferi

Arthritis Rheum. 1994 Jul;37(7):1070-7. doi: 10.1002/art.1780370713.


Objective: The arthritogenic potential of the cationic outer surface proteins (Osp) from Borrelia burgdorferi was tested in rats.

Methods: Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology.

Results: A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation.

Conclusion: The Osps of Borrelia burgdorferi are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology
  • Arthritis, Infectious / etiology*
  • Arthritis, Infectious / immunology*
  • Arthritis, Infectious / microbiology
  • Bacterial Outer Membrane Proteins / pharmacology*
  • Borrelia burgdorferi Group* / chemistry
  • Inflammation / diagnostic imaging
  • Lyme Disease*
  • Male
  • Radionuclide Imaging
  • Rats
  • Rats, Wistar
  • Recombinant Proteins / pharmacology
  • Synovial Fluid / chemistry
  • Technetium


  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Recombinant Proteins
  • Technetium