Crosstalk in the mouse thymus

Immunol Today. 1994 May;15(5):214-7. doi: 10.1016/0167-5699(94)90246-1.


The development of mature T cells within the thymus is dependent upon intact cortical and medullary microenvironments. In turn, thymic microenvironments themselves are dependent on lymphoid cells to maintain their integrity. Here, Willem van Ewijk and colleagues discuss experiments that have established the phenomenon of 'crosstalk' within the mouse thymus and suggest a mechanism whereby lymphoid and stromal cells influence each other in a consecutive manner during T-cell development.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Lymphocytes / physiology
  • Mice
  • Stromal Cells / physiology
  • T-Lymphocytes / physiology*
  • Thymus Gland / cytology*