Nervous tissue as an immune compartment: the dialect of the immune response in the CNS

Immunol Today. 1994 May;15(5):218-24. doi: 10.1016/0167-5699(94)90247-X.


Here, Zsuzsa Fabry and colleagues address the question of whether the unique cellular environment of the central nervous system (CNS) contributes to the observed differences in immunological functions between the CNS and other organs. In particular, they discuss the significance within the CNS of the blood-brain barrier, the nonconstitutive expression of major histocompatibility complex (MHC) molecules, the unusual set of potential antigen-presenting and effector cells, and the production of immune or neuromediators from various cellular sources.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood-Brain Barrier / immunology
  • Cell Adhesion Molecules / immunology
  • Central Nervous System / cytology
  • Central Nervous System / immunology*
  • Cytokines / biosynthesis
  • Humans
  • Major Histocompatibility Complex / immunology


  • Cell Adhesion Molecules
  • Cytokines