Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

Immunol Today. 1994 May;15(5):225-34. doi: 10.1016/0167-5699(94)90248-8.


A central question in T-cell immunity concerns the nature of intracellular signaling from the antigen receptor, the CD4/CD8 co-receptors and the CD28 antigen. Since the original discovery that T-cell receptors such as CD4 can interact with intracellular protein-tyrosine kinases such as p56lck, remarkable progress has been made in deciphering the signaling pathways that control T-cell growth and immune function. Here, Christopher Rudd and colleagues examine the role of protein-tyrosine kinases, SH2/SH3 domains and lipid kinases in the generation of signals from the TCR zeta/CD3 complex and the CD28 antigen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / immunology*
  • Binding Sites
  • CD28 Antigens / immunology
  • CD3 Complex / immunology
  • CD4 Antigens / immunology
  • Humans
  • Membrane Proteins / immunology*
  • Molecular Sequence Data
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology*
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology*


  • Antigens, CD
  • CD28 Antigens
  • CD3 Complex
  • CD4 Antigens
  • Membrane Proteins
  • Receptors, Antigen, T-Cell
  • antigen T cell receptor, zeta chain
  • Phosphotransferases (Alcohol Group Acceptor)
  • Protein-Tyrosine Kinases