Regulation of the Human Neutrophil NADPH Oxidase by the Rac GTP-binding Proteins

Curr Opin Cell Biol. 1994 Apr;6(2):212-8. doi: 10.1016/0955-0674(94)90138-4.


Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the GTP/GDP state of Rac. Proteins exist in leukocytes that are able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated upon phagocyte stimulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemotaxis, Leukocyte
  • GTP-Binding Proteins / metabolism*
  • Guanosine Diphosphate / blood
  • Guanosine Triphosphate / blood
  • Homeostasis
  • Humans
  • Models, Biological
  • NADH, NADPH Oxidoreductases / blood*
  • NADPH Oxidases
  • Neutrophils / physiology*
  • Phagocytosis*
  • rac GTP-Binding Proteins


  • Guanosine Diphosphate
  • Guanosine Triphosphate
  • NADH, NADPH Oxidoreductases
  • NADPH Oxidases
  • GTP-Binding Proteins
  • rac GTP-Binding Proteins