Long-range intercellular signalling in glial cells of the peripheral nerve

Neuroreport. 1994 Jan 31;5(5):635-8. doi: 10.1097/00001756-199401000-00026.

Abstract

Schwann cells are considered to be electrically silent satellite cells surrounding axons, although they exhibit ionic channels, some of which are similar to those employed by axons for the generation and transmission of nerve impulses. Here, we show that Schwann cells generate, in response to a short and gentle electrical stimulus, a long-lasting depolarizing potential, slowly propagating along the Schwann cell synsitium. This electrical signal, which in situ might be generated by the Schwann cells in response to the axonal electrical activity, constitutes in the peripheral glia a novel form of long-range intercellular signalling, which may be involved in the regulation and modulation of the axonal excitability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / physiology
  • Calcium / physiology
  • Chlorides / pharmacology
  • Electric Stimulation
  • Female
  • Male
  • Membrane Potentials / drug effects
  • Peripheral Nerves / physiology*
  • Rabbits
  • Schwann Cells / physiology*
  • Sodium / pharmacology
  • Tetrodotoxin / pharmacology
  • Vagus Nerve / physiology
  • Vagus Nerve Injuries
  • Wallerian Degeneration

Substances

  • Chlorides
  • Tetrodotoxin
  • Sodium
  • Calcium