Functional perfusion and blood-brain barrier permeability images in the diagnosis of cerebral tumors by Angio CT

Comput Med Imaging Graph. May-Jun 1994;18(3):145-50. doi: 10.1016/0895-6111(94)90023-x.


We performed rapid sequential CT scanning following iv injection of a bolus of contrast medium and generated three functional images relating to intravascular circulation time (rABCT), vascular volume (Vv) density and blood-brain barrier (BBB) unidirectional constant uptake rate (Ki), respectively. This was accomplished by calculating the first mathematical moment of the monitored time-density curves about the injection time and from the multiple time graph analysis described by Patlack and co-workers. A satisfactory resolution was achieved, allowing separate appreciation of changes in rABCT both in large vessels and in tissue small vessels. Combined evaluation of rABCT and Vv images allowed us to differentiate between tumors.

MeSH terms

  • Blood Volume / physiology
  • Blood-Brain Barrier / physiology*
  • Brain / blood supply
  • Brain Neoplasms / blood supply
  • Brain Neoplasms / diagnostic imaging*
  • Cerebral Angiography / methods*
  • Cerebrovascular Circulation / physiology*
  • Contrast Media / administration & dosage
  • Contrast Media / pharmacokinetics
  • Craniopharyngioma / blood supply
  • Craniopharyngioma / diagnostic imaging
  • Glioblastoma / blood supply
  • Glioblastoma / diagnostic imaging
  • Glioma / blood supply
  • Glioma / diagnostic imaging
  • Humans
  • Meningioma / blood supply
  • Meningioma / diagnostic imaging
  • Permeability
  • Radiographic Image Enhancement
  • Time Factors
  • Tomography, X-Ray Computed / methods*


  • Contrast Media