Multiple occurrence of carcinoma in the upper aerodigestive tract associated with esophageal cancer: reference to smoking, drinking and family history

Int J Cancer. 1994 Jul 15;58(2):207-10. doi: 10.1002/ijc.2910580211.


Smoking and drinking habits as well as family history were examined in 143 men with esophageal cancer, including 30 who had associated second cancers of the upper aerodigestive tract (UADT) and 113 who did not. The risk of second cancers of UADT associated with the main lesions of the esophagus was evaluated, using odds ratios (ORs). As a result, the ORs of second cancers for current smoking and drinking were 5.3 and 7.6 respectively. The ORs significantly increased to 12.7 and 14.7 in heavy smokers and in heavy drinkers respectively. Furthermore, the risk of second cancer also significantly increased (8-fold) in patients who had close relatives with UADT cancer, compared to those without family history of any cancer. However, there were no differences in smoking or drinking habits regardless of family history. Our data thus suggest that a family history of UADT cancer as well as heavy smoking and drinking are clearly associated with multiple occurrence of UADT cancer. Therefore, careful and frequent examination for appearance of any second lesions are required for patients in these high-risk groups.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Alcohol Drinking / adverse effects
  • Digestive System Neoplasms / epidemiology*
  • Digestive System Neoplasms / etiology
  • Digestive System Neoplasms / genetics
  • Esophageal Neoplasms / epidemiology*
  • Esophageal Neoplasms / etiology
  • Esophageal Neoplasms / genetics
  • Family Health
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / epidemiology*
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / genetics
  • Respiratory Tract Neoplasms / epidemiology*
  • Respiratory Tract Neoplasms / etiology
  • Respiratory Tract Neoplasms / genetics
  • Risk Factors
  • Smoking / adverse effects