Acute and chronic nicotine effects on multiple-schedule behavior: oral and SC routes

Pharmacol Biochem Behav. 1994 May;48(1):209-15. doi: 10.1016/0091-3057(94)90518-5.


For rats responding on a 3 h FI 4 min FR 20 schedule of food reinforcement, presession SC nicotine doses (0.1-0.8 mg/kg) produced depression in all responding followed by stimulation of FI responding that was dependent upon both time and dose. With daily presession 0.8 mg/kg SC nicotine injections for 9 days, no tolerance to the depressive or stimulatory effects of nicotine occurred. When nicotine solutions were orally self-administered by presession exposure to 3 h of schedule-induced polydipsia, the subsequent FR responding was unaffected, but the degree of FI response stimulation and its duration occurred in a dose-related fashion (1.18-4.10 mg/kg). Prolonged daily sessions of oral nicotine self-administration provide a technique for investigating the effects of chronic exposure to nicotine. The postingestive effects of nicotine reveal stimulatory effects that last for at least 3 h.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Conditioning, Operant / drug effects*
  • Dose-Response Relationship, Drug
  • Drinking / drug effects
  • Drug Tolerance
  • Injections, Subcutaneous
  • Male
  • Nicotine / administration & dosage
  • Nicotine / pharmacokinetics
  • Nicotine / pharmacology*
  • Rats
  • Reinforcement Schedule
  • Self Administration


  • Nicotine